Elsewhere in the region, the leu’s peers were losing around 0.6% on average versus the European currency.
The leu opened down at 4.223/4.235 per euro, and further lost ground, with investors fearing Greece’s debt crisis could spread to eurozone periphery.
The central bank set the leu’s reference at 4.2356 to the euro, 0.26% weaker on the day.
Against the Swiss franc, the leu hit a new historic low of 3.8269 units, from 3.711 units Monday. The leu fell against the US dollar as well, losing over 2% at 2.9864 units.
On the money market, overnight rates fell to 4.1%-4.6% a year, from 4.3%-4.8% a year in the previous session.