Romanian Prime Minister Victor Ponta and Transport Minister Relu Fenechiu will be present at the inauguration.
The bridge between Giurgiu and Ruse is currently the only bridge over the Danube on the Romanian-Bulgarian border.
In 2000, Romania and Bulgaria signed an agreement to build a second bridge, between Calafat and Vidin, but the project has been delayed because of funding issues.
The 1,791-meter Calafat-Vidin bridge is part of Pan-European Corridor IV linking Dresden (Germany) to Istanbul (Turkey).
Construction costs reached almost EUR300 million. According to Transport Ministry data, Romania secured some EUR72.5 million, of which EUR36.6 million came from the state budget and the remainder from EU pre-accession funds.
Bulgaria contributed approximately EUR226 million, with EUR61 million coming from the state budget and the remainder from EU pre-accession funds, the European Investment Bank, the French Development Agency and German bank KfW.